Important notice:

Aflibercept injection is available as different products that are biologic medications (medications made from living organisms). These biologic products are considered to be "biosimilar" to afibercept injection which means they work as well and are just as safe to use as afibercept injection. Afibercept injection mentioned in the monograph below refers to any of these products.

Why is this medicine prescribed?

Aflibercept injectionis used to treat:

• wet age-related macular degeneration (AMD; an ongoing disease of the eye that causes loss of the ability to see straight ahead and may make it more difficult to read, drive, or perform other daily activities)
• diabetic macular edema (an eye disease caused by diabetes that can lead to vision loss)
• diabetic retinopathy (damage to the eyes caused by diabetes)
• macular edema after retinal vein occlusion (an eye disease caused by blockage of blood flow from the eye that leads to blurry vision and vision loss)
• retinopathy of prematurity (ROP; an eye disease that occurs in premature infants that can lead to vision loss and blindness)

Aflibercept injection products are in a class of medications called vascular endothelial growth factor-A (VEGF-A) and placental growth factor (PlGF) antagonists. They work by stopping abnormal blood vessel growth and leakage in the eye(s) that may cause vision loss in people with certain eye conditions.

Are there other uses for this medicine?

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

How should this medicine be used?

Aflibercept injection comes as a solution (liquid) to be injected into the eye by a doctor. It is given in a doctor's office or healthcare facility. Your doctor will give you injections on a schedule that is best for you and your condition.

Before you receive aflibercept injection, your doctor will clean your eye to prevent infection and numb your eye to reduce discomfort during the injection. After your injection, your doctor will need to examine your eyes before you leave the office.

Aflibercept injection controls certain eye conditions, but does not cure them. Your doctor will watch you carefully to see how well aflibercept injection works for you. Talk to your doctor about how long you should continue treatment with an aflibercept injection.

What special precautions should I follow?

Before receiving aflibercept injection,

• tell your doctor or pharmacist if you are allergic to this medication, any part of this medication, or any other medications, foods or substances. Tell your doctor or pharmacist about the allergy and what symptoms you had.

• tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take.

• tell your doctor if you have an infection or swelling in or around the eye. Your doctor will probably tell you that you should not receive aflibercept injection.

• tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. You should not become pregnant right before starting your treatment and during your treatment, and for 3 to 4 months after your last injection. Use effective birth control before and during your treatment, and for 3 to 4 months after your final dose. If you become pregnant while receiving aflibercept injection, call your doctor.

• you should know that aflibercept injection may cause vision problems shortly after you receive the injection. Do not drive a car or operate machinery until your vision is back to normal.

What special dietary instructions should I follow?

Unless your doctor tells you otherwise, continue your normal diet.

What should I do if I forget to take a dose?

If you miss an appointment to receive aflibercept injection, call your doctor as soon as possible.

What side effects can this medicine cause?

Aflibercept injection may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

• feeling that something is in your eye
• teary eyes

Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately or get emergency medical treatment:

• eye redness or pain, sensitivity to light, blurred vision, decrease or changes in vision, seeing floaters or small specks, seeing flashing lights
• chest pain, shortness of breath, sweating, slow or difficult speech, dizziness or faintness, weakness or numbness of an arm or leg
• rash, itching, hives, difficulty breathing or swallowing

Aflibercept injection products may cause other side effects. Call your doctor if you have any unusual problems while receiving this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (https://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

What other information should I know?

Keep all appointments with your doctor. Your doctor will monitor your response to aflibercept injection.

Ask your pharmacist any questions you have about aflibercept injection.

Keep a written list of all of the prescription and nonprescription (over-the-counter) medicines, vitamins, minerals, and dietary supplements you are taking. Bring this list with you each time you visit a doctor or if you are admitted to the hospital. You should carry the list with you in case of emergencies.

Brand name(s)

• Ahzantive^®(aflibercept-mrvv)
• Enzeevu^®(aflibercept-abzv)
• Eydenzelt^®(aflibercept-boav)
• Eylea^® (aflibercept)
• Eylea^® HD (aflibercept)
• Opuviz^® (aflibercept-yszy)
• Pavblu^® (aflibercept-ayyh)
• Yesafili^® (aflibercept-jbvf)

This report on medications is for your information only, and is not considered individual patient advice. Because of the changing nature of drug information, please consult your physician or pharmacist about specific clinical use.

The American Society of Health-System Pharmacists, Inc. represents that the information provided hereunder was formulated with a reasonable standard of care, and in conformity with professional standards in the field. The American Society of Health-System Pharmacists, Inc. makes no representations or warranties, express or implied, including, but not limited to, any implied warranty of merchantability and/or fitness for a particular purpose, with respect to such information and specifically disclaims all such warranties. Users are advised that decisions regarding drug therapy are complex medical decisions requiring the independent, informed decision of an appropriate health care professional, and the information is provided for informational purposes only. The entire monograph for a drug should be reviewed for a thorough understanding of the drug's actions, uses and side effects. The American Society of Health-System Pharmacists, Inc. does not endorse or recommend the use of any drug. The information is not a substitute for medical care.

AHFS^® Patient Medication Information™. © Copyright, 2026. The American Society of Health-System Pharmacists^®, 4500 East-West Highway, Suite 900, Bethesda, Maryland. All Rights Reserved. Duplication for commercial use must be authorized by ASHP.

Selected Revisions: January 15, 2026.